With my autoimmune diseases I was unable to take the big 3. My doctor was not pleased with me. After writing to my pulmonologist to give me 7% sodium chloride, he begrudgingly prescribed. I do the vest and 7% 30 minutes twice a day. It hasn't cured me, but in the past year, nodules have disappeared, new ones have appeared, but my breathing test and ct scans over the past year are the same. Nothing has gotten worse and breathing test was slightly improved.
Two of my other doctors felt I could never tolerate the meds and I knew I could not. I have MAC and bronchiectasis with occasional coughing up blood. I believe there are other methods besides the big 3.
Lorraine

It is amazing the different ways patients are advised and what they take and don't take. I also take NAC 600 mg twice a day. Can't pinpoint if it makes any difference because I do so much other stuff. I was hospitalized eight days for COVID and because my cough was so bad they gave me Mucinex which helped settle it down. My post-hospital pulm doc visit said he did not recommend taking Mucinex regularly because it might suppress the cough when you actually need to cough to expel sputum. I neb twice daily with 3.5% sodium chloride and am inhaling Tobramycin (2 weeks on and 2 weeks off). Have had pseudomonous A. return over and over for more than four years. It's a battle and we just need to find our best weapons. Best to everyone.

I tried the NAC and it made my arthritis flare. If you don’t have arthritis, it is can be good for the mucous.