I do not have MAC (as far as I know) but if I did I know the three antibiotics would be impossible for me. I have Bronchiectasis and chronic Pseudomonas. I struggle with other health issues that are preventing me from taking antibiotics and am trying to find out why but thus far Drs have not given me the answers I need. I nebulize 7% saline followed by Aerobika flutter device twice a day. It takes me an hour the first time and maybe 40 minutes the second time.