1. < MAC & Bronchiectasis

Anyone familiar with pH balanced 7% saline, rather than acidic type?

Posted by poodledoc @poodledoc, May 12, 2022

I was searching for information on how Upper Airway Reflux may influence Bronchiectasis and came across this interesting 7% saline called PulmoSal™ 7% (pH+) Bio-Balanced™ Hypertonic Saline. Which may be better than the more acidic type that most of us are probably using. Does anyone use this or know anything about it? The information on their website is compelling.
https://www.pharmacaribe.com/our-products/pulmosal-7-ph/

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poodledoc | @poodledoc | Oct 24, 2022

I think everyone in this forum would agree that nebulizing saline regardless of strength or pH is a very important part of airway clearance for Bronchiectasis and/or NTM. https://bronchiectasisnewstoday.com/bronchiectasis-experimental-treatments/hypertonic-saline-solution/?cn-reloaded=1

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1 reply
irenea8 | @irenea8 | Oct 25, 2022
In reply to @heathert "THE ROLE OF THE CELL ENVELOPE IN ACID RESISTANCE At an external pH of 5, the..." + (show)
@heathert

THE ROLE OF THE CELL ENVELOPE IN ACID RESISTANCE

At an external pH of 5, the internal pH of M tuberculosis H37Ra was close to 7, indicating that mycobacteria are able to maintain a neutral internal pH in an acidic environment (105), and other studies have confirmed this observation in M. smegmatis and virulent M.22/05/2009

Acid Resistance in Mycobacterium tuberculosis - PMC - NCBIhttps://www.ncbi.nlm.nih.gov › articles › PMC2715723

Not Quite what you were after @poodledoc but quite interesting.

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what does this mean exactly? does it mean Mycobacteria will not be affected one way or the other by a less acidic saline?

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raney | @raney | Oct 30, 2022
In reply to @poodledoc "I think everyone in this forum would agree that nebulizing saline regardless of strength or pH..." + (show)
@poodledoc

I think everyone in this forum would agree that nebulizing saline regardless of strength or pH is a very important part of airway clearance for Bronchiectasis and/or NTM. https://bronchiectasisnewstoday.com/bronchiectasis-experimental-treatments/hypertonic-saline-solution/?cn-reloaded=1

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What does that mean to us unscientific people?

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