Colleen, I have no symptoms other than some fatigue. I am taking aspirin as prescribed by Dr. My concern about starting Hydrea is how it will affect my quality of life at this stage. If I had some other more obvious symptoms that debilitated me, I would consider it perhaps. But, truthfully, I feel very lucky to have lived to 80 with relatively good health, and I will be very thankful for whatever time I have left without taking a chemo drug that could affect my every day life. If I were in my 60s, I might feel differently.