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Mycophenolate or Myfortic: Do you have GI side effects?

Transplants | Last Active: Dec 2, 2023 | Replies (54)
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@bosco17

When they reduced your dosage of Mycophelonate ,what did they reduce it to ? Im on the lowest dose possible 500mg -2x daily . Note that this is the only anti-rejection drug Im on and reducing the dosage is very risky for rejection. I dont think Im allowed to reduce the dosage as that is the only anti-rejection drug I take. What are your thoughts?

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Replies to "When they reduced your dosage of Mycophelonate ,what did they reduce it to ? Im on..."
hello1234 | @hello1234 | Oct 30, 2022

Good morning @bosco17 😊
Yes, you are correct that the "standard" protocol dose of Mycophenolate is 1,000mg twice a day.
That level of Mycophenolate gave me severe neutropenia and leukopenia.
Because it was the first year post kidney transplant, the nurse coordinator was concerned to reduce dosage. My local nephrologist was concerned that I was over-immune suppressed and would get sick.
I got sick.
I was diagnosed with active CMV. My Mycophenolate was reduced to 500mg twice a day.
A year later, I now have the BK virus so my Mycophenolate is reduced again to 250mg bid.
I also take 6mg Envarsus XR (Tacronlimis) to achieve the target blood range of 6 to 8.
I take my meds with food in an attempt to buffer my stomach. If I had to guess, I think your doc will want to make the switch from Mycophenolate to Myfortic at your equivalent lower dosage to see if that does the trick to alleviate your GI issues. (They may also offer a couple months of PPI to help heal your stomach unless you have had a bad experience with PPI.)
It sounds like Myfortic has worked very successfully for @katebw and @myfablife so I am very hopeful that will be your easy solution too!! ❤
Will you please come back and post after your conversation with the doctor and let us know how it goes?

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