Thank you so much for taking the time to answer. I am amazed when i read about people who are able to take so many antibiotics! I am thinking you must be younger with fewer co morbidities than myself. I have had Bronchiectasis for a long time since around 2000 and I am 71. But I also have chronic long standing intestinal issues and also possibly kidney and heart issues that are undiagnosed. I recently (March) found out I have Chronic Pseudomonas (mucoid strain found). The only antibiotics I have ever used are Augmentin twice and in August tried inhaled Toby but only got through 5 treatments due to side effects! My main issue each time is that I stop urinating enough. Out of all the options to try inhaled Cayston seemed the least likely to have that effect (reading about it). But I know I would not be able to use it ongoing. I was hoping that a couple of weeks of it would at least knock things back. From what I am reading and from studies it seems that it does not help NCFB as much. Did you find it helpful at first? Did you have side effects with it? Also curious about the Meropenem. Did that help at all? It is supposed to be relatively safe for kidney issues. And the Colistin studies show it helps NCFB with Pseudomonas the most. But I thought it was not approved by the FDA and has very bad side effects. What have you experienced with it? All I do is nebulize saline 7% twice a day followed by Aerobika and nebulized Glutathione a few times a week. I recently started trying PulmoSal saline which is supposed to be less acidic and therefore help to reduce Pseudomonas better. So far it seems good. And I started using the Aerobika not just sitting but also laying on my back and sides. That has made a big difference. Thanks again and anything more about the Cayston or Meropenem or Colistin would be appreciated. Need to read up on Bactrim but curious about it too.