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I have JAK2 ET and MPN: Anyone else have these symptoms?

Blood Cancers & Disorders | Last Active: Nov 28, 2023 | Replies (49)
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@nohrt4me

Thanks. New to me. My hematologist prescribes hydroxyurea as first-line drug when indicated by IPSET guidelines (driver mutation, age, clot history).

I know that the leukemia-hydroxyurea link has been studied, debated, and argued for a long time. Is new research showing that the TET2 mutation triggers progression to AML when the patient is on hydroxy?

Just thinking about whether it's worth it to ask about more genetic testing at my next visit. I'm 68, insurance would not cover Pegasys, so maybe moot for me.

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Replies to "Thanks. New to me. My hematologist prescribes hydroxyurea as first-line drug when indicated by IPSET guidelines..."
amybh | @amybh | Oct 26, 2022

That is what my oncologist was concerned with, he seems to be under impression that it would/could happen quickly if it is a genetic mutation.
They ordered my test through Invitae. It might be worth looking into. I was told currently I need to do lab draws every 3 months and if I go on Hydroxy then it would be every three weeks. My head is in a constant spin not knowing which way to turn.

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