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I have JAK2 ET and MPN: Anyone else have these symptoms?

Blood Cancers & Disorders | Last Active: Jun 19 5:40am | Replies (63)
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@amybh

TET2 is a gene mutation that was found during my bone marrow biopsy. They currently do not want to try Hydroxyurea with me until my genetic testing is completed. If this mutation is genetic the odds of it mutating to leukemia on the Hydroxyurea is very high. I do not have valve issues but I do have a cardiac history, which makes me a bit nervous with this new diagnosis of ET.

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nohrt4me | @nohrt4me | Oct 25, 2022

Thanks. New to me. My hematologist prescribes hydroxyurea as first-line drug when indicated by IPSET guidelines (driver mutation, age, clot history).

I know that the leukemia-hydroxyurea link has been studied, debated, and argued for a long time. Is new research showing that the TET2 mutation triggers progression to AML when the patient is on hydroxy?

Just thinking about whether it's worth it to ask about more genetic testing at my next visit. I'm 68, insurance would not cover Pegasys, so maybe moot for me.

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