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I have JAK2 ET and MPN: Anyone else have these symptoms?

Blood Cancers & Disorders | Last Active: Jun 19 5:40am | Replies (63)
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@nohrt4me

Is TET2 a new driver mutation? All I have heard of is JAK2, CALR, and MPL. I have ET-CALR. Ditto on the fatigue, though hydroxyurea helped with that. Hands and feet are often burning hot or ice cold.

However, I am 68 and also have heart valve issues, so it's hard to know the root cause of it all.

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Replies to "Is TET2 a new driver mutation? All I have heard of is JAK2, CALR, and MPL...."
amybh | @amybh | Oct 25, 2022

TET2 is a gene mutation that was found during my bone marrow biopsy. They currently do not want to try Hydroxyurea with me until my genetic testing is completed. If this mutation is genetic the odds of it mutating to leukemia on the Hydroxyurea is very high. I do not have valve issues but I do have a cardiac history, which makes me a bit nervous with this new diagnosis of ET.

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