My husband has had Crohns all his life. He had a temporary colostomy at 40 yrs old, reversed a year later then permanent one a year later. He tried Humira monthly infusion treatments at 50 but he became diabetic so switched to Remicade. He is 76 and going strong. What worked: he was old school and still does morning enemas to remove waste and gets the day off to a good start, 6 weeks Remicade infusions, and gets vaccines. No pain, no flares but sticks to a routine. It is genetic in his family.