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Wife newly diagnosed with NSCLC

Posted by daveb482 @daveb482, Oct 8, 2022

My wife had persistent cough some May. After X-ray indicated pneumonia potential in Right Middle Lobe (RML) two rounds of antibiotics , finally recommended pulmonologist to go in and take samples, adenocarcinoma found in RML. Follow up included CT and PET scans currently staged as IV as there is a nodule in lower right lung and left lower. Surgery ruled out, Radiation ruled out. No matching for targeted therapy drugs. Will be starting Carboplatin and Alimta chemotherapy with Keytruda immunotherapy. This will also be long term maintenance as required. Any comments?

Interested in more discussions like this? Go to the Lung Cancer Support Group.

Mentor
Lisa, Volunteer Mentor | @lls8000 | Oct 16, 2022
In reply to @daveb482 "A Pulmonologist performed a biopsy from which a portion was sent to Foundation Medical which performed..." + (show)
@daveb482

A Pulmonologist performed a biopsy from which a portion was sent to Foundation Medical which performed the analysis that looked at the cancer cell genotypes and determined no matches to existing target drugs, got a 15 page report from them.

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Foundation Med is very thorough. That’s exactly what they should have done. Sorry that she wasn’t a match for a targeted therapy.

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Moderator
Colleen Young, Connect Director | @colleenyoung | Oct 16, 2022
In reply to @patneo2 "Exon 21 L858R adenoccarcinoms T790m not detected My wife was diagnosed on July right lower lung..." + (show)
@patneo2

Exon 21 L858R adenoccarcinoms T790m not detected
My wife was diagnosed on July right lower lung tumor 2.5 x1.8 and mele both lungs and slight on 8th ribs. Onc dun need chem or ops - do target : Tagrisso 80mg 2 days once. All went well . Tumor shrink by 1cm , left clear - right a slight water. 3 months.
But last week - for 2 days , she feel breathless and cough . Went in hospital on tue- only right lungs for fluid - drain out 2.2 litre - stay 3 days , fluid is pinky. Pleural Fluid 40mg finding back as metastic non small cell carcinoma compatible with adenoccarcinoms. Culture report not out.
Can advise - is this bad ? is this MPE ? Or ?? Targisso still work ?? Thanks

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Welcome @patneo2 to Mayo Clinic Connect, a place where you can connect with other lung cancer patients and family caregivers. I moved your message to this existing discussion so you can connect with @daveb482 and others:

- Wife newly diagnosed with NSCLC https://connect.mayoclinic.org/discussion/wife-newly-diagnosed-with-nsclc/

Pat, as fellow patients and caregivers, we can't answer medical questions, but we can support you on the journey. Is your wife continuing with Targisso? How is she doing?

@daveb482, thinking of you as you prepare for your wife's appointment at Mayo tomorrow.

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daveb482 | @daveb482 | Oct 22, 2022

Three days at Mayo an emotional roller coaster, initially team felt surgery was an option. However new enhanced CT scan revealed two nodules in left lung, too much right lung removal would compromise health. So it looks like we’re back to drug trial decision, Tuesday consult with trial doctor.

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1 reply
Moderator
Colleen Young, Connect Director | @colleenyoung | Oct 29, 2022
In reply to @daveb482 "Three days at Mayo an emotional roller coaster, initially team felt surgery was an option. However..." + (show)
@daveb482

Three days at Mayo an emotional roller coaster, initially team felt surgery was an option. However new enhanced CT scan revealed two nodules in left lung, too much right lung removal would compromise health. So it looks like we’re back to drug trial decision, Tuesday consult with trial doctor.

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Oh Dave. That does sound like a physical and emotional roller coaster. So exhausting. How did the consult on Tuesday go? New plan?

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daveb482 | @daveb482 | Oct 30, 2022

We are going for the clinical trial if Diane meets their criteria. Two days of various tests and scans Monday and Tuesday. Results go to drug company and if they approve will start on 14th. If not we go home and do the standard 3 drug protocol.

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dedehans | @dedehans | Oct 30, 2022

Dave, I hope and pray that Diane gets into a clinical trial. Please keep us posted. I am curious as to what Foundation Medicine had to say...

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daveb482 | @daveb482 | Oct 30, 2022

Look back at my posts Foundation Medical found no matches, that was 3 weeks ago.

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