Very very long story short. I am a 71 year old female. ALL my life I've struggled, been so uncomfortable, felt sick. I learned to live with it,....mostly. After many years I finally learned that I have a tortuous intestine, too big for a person my size (5'2" and about 100 lbs.) I have a very slow transit time as a result. This causes constipation. Nothing really worked for me. Nothing. I just got lucky and had a bowel movement now and then with much discomfort inbetween. FINALLY, on this site, someone recommended Prunelax. It is sold at Walmart over the counter and other drug stores. Probably online also. I started with the mini tabs and I took 4 every evening about 7:30pm. Now I take Prunlax Maximum Relief, 2 1/2 pills each evening. They are larger in size but the dosage is similar. I cut one in half with a pill splitter. I have never felt better in my life. My gastro doctor also reassured me that I could continue taking this. It will eventually change the internal color of the colon due to the senna but it is not harmful. It actually provides the gastro doctor a better picture of the colon if a colonoscopy is done. (Which I personally am done with because it is so risky with my colon with all it's twists and turns. It could be punctured with the colonoscopy. AND I was miserable for days after the procedure. There are other ways to do this procedure.) I have tried everything that the doctors ordered, Miralax, drink lots of water, which I do, fiber, which I do, other products that are normally prescribed. Nothing worked. But Prunelax does. I hope this helps and please pass the word because there has never been one doctor in my entire experience with this situation that recommended it. Best wishes. Jacque