Hi @barbakp, It was overwhelming for me for quite a while as well. My mother and my aunts had severe osteoporosis and I was always an avid exerciser trying to keep it at bay, but that wasn't enough. I had a number of other risk factors working against me. I elected to take alendronate, reluctantly. I'm doing the yoga daily and also taking some supplements. I hope to read the COMB study and discuss with my rheumatologist next week. I haven't had any side effects from the alendronate so far, but if I could improve my bone density and get off it, I'd be happy.