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Invasive ductal carcinoma (IDC): Anyone else?
Breast Cancer | Last Active: Mar 24 10:10am | Replies (223)Comment receiving replies
What does it mean surgically rendered tissue?
My understanding is that Oncotype is done after the surgery. But it make sense to do it before the surgery to see if the tumor is aggressive.
There is another test called Ki 67 proliferation index.
When I asked the surgeon on September 21st about Oncotype and Ki67, she told me that they do it after surgery. Not only, but if she finds positive nodes they don't do Oncotype. Mount Sinai.
Replies to "What does it mean surgically rendered tissue? My understanding is that Oncotype is done after the..."
Good morning. By “surgically rendered tissue” I meant the tumor taken at the time of surgery verses the tissue from the biopsy. My oncologist submitted biopsy tissue for the ONCOTYPING.
My presumption is that your surgeon ( Mt Sinai) will order chemo, if node positive, in any case so why bother with ONCOTYPE ( which may suggest that chemo is not needed). Yes, I’m familiar with KI 67. It is among one of the values considered. I was right at the cusp of where it becomes “aggressive”. It appears in the research that the ONCOTYPE DX is the more relied upon measure. There is research on this. I read every study I could get my internet hands on. Lots of research posted from Canada, England, and other European countries.
I think you are wise to get a second opinion. I did also.
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Oncotype is recommended for those with 1-3 nodes positive.
Ki67% is actually one of the proliferative factors included in the Oncotype but there are several. My ki67% was high but my Oncotype was low so I called Genomic Health to ask them. Also I had grade 3 and they told me 30% of grade 3's have low Oncotypes.
Many docs don't order the ki67% because it is considered unreliable. I still wonder if healing biopsy tissue threw mine off.