Update: As my spouse is also a Mayo patient, while in Rochester in late October, on the advice of my local oncologist, we contacted a Mayo physician, who in concert with my local oncologist, devised a strategy to minimize the reaction to bendamustine. Prior to that next dose, I underwent a PET scan to determine if, in fact, the bendamustine was working. Result was that there was significant progress on tumor sizes and SUV across my affected area! So I underwent another bendamustine infusion along with nivolumab and the revised strategy worked! My only side reactions to the bendmustine were relatively mild. Some digestive issues and dry mouth were noted, but managed. So we are on track for several more months of bendamustine! Thanks to Mayo for suggesting bendamustine and for helping manage side effects!