@echo2022, I need to add to my reply.
My Tacrolimus dose has been stable in recent years. I forgot to mention that there were adjustments that I had forgotten about and I want to let you know about that.
I remember 2 occasions when my concentration, ability to focus on a task, and significant tremors were affecting me. After a call to transplant nurse my dose was lowered by 0.5 mg. I felt immediate relief and my labs remained normal. That was at least 5 years ago. I also remember when my trough level was low and my ‘regular’ dose was raised 0.5 mg and I was miserable with tremors and anxiety-like effects. The dose was returned to my ‘normal’ 1.5 where it is currently.
I don’t recall any sleep issues.