Hi Stan, I have not been on here in a while. Are you continuing to feel the benefits of the treatment? After 3 years of watch and wait I am to begin single agent Rituxan in mid January due to my spleen size more than anything else. I believe you mentioned you could feel your spleen shrink, has that continued also? I've been told it will never go back to normal, too stretched out. Thank you for sharing your initial difficulties, as I am forewarned the first treatment is likely rough. The dr. confirmed this likelihood but said that means its working. How did you make decisions about isolation? Were they following your immune factors to help you decide when to rejoin society in general? Hope you did not suffer any infections as they recovered. I don't recall how long from your time of diagnosis to this first treatment. I feel pretty lucky to have had 3 years. I believe I did read an entry in a forum of a patient who received one treatment and never needed another and he was 8 years out! Not my expectation, but good to hear anyway. Good luck with your mid November checkup. Theresa