1. < Pancreatic Cancer

Is anyone participating in a clinical trial for pancreatic cancer?

Posted by lfitz @lfitz, Sep 25, 2022

Is anyone participating in a clinical trial for pancreatic cancer? My husband’s PC is not genetic. He has tried Folfirinox. He was allergic to Oxaliplatin and the Folfiri was not effective. He did Xeloda during his radiation. He did 2 months of Gemcitibine and Abraxane with severe side effects and no good days during the 2 months. It did work well though. He has grade 3/4 neuropathy. He is now stage 4 and only options appear to be no treatment and enjoy what time he has left, a decreased dose of gemcitibine and abraxane , or a clinical trial.

Interested in more discussions like this? Go to the Pancreatic Cancer Support Group.

nahyduk | @nahyduk | Sep 26, 2022

A family member just signed up for a clinical trial thru Henry Ford Health System, Detroit. Chemo failed to reduce inoperable tumor. Radiation + Clinical trial are next. He sees Dr. Kwon. Hope this is helpful. I’m not sure all of the details.

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stageivsurvivor | @stageivsurvivor | Sep 26, 2022

Early in my treatment on Folfirinox for metastatic disease to the liver, I got genetically tested and found to have a gene mutation. When the effectiveness of Folfirinox began waning, I enrolled in a clinical trial in 2014. I had a complete response resulting in NED since.

There are many types of clinical trials that are not dependent on having a gene mutation. There are drugs designed to interrupt/shut down the cell energy cycle of malignant cells. Immunotherapy targeting check-point inhibitors is another area of active research. PanCan.org and LetsWinPC.org have a clinical trials finder as does clinicaltrials.gov. There are several companies that will help narrow down potential trials that do the searches at no charge. Look into the websites EmergingMed.com, CancerCommons.org, myTomorrows.com and Ancora.ai. Clinical trials offer late-stage pancreatic cancer patients the potential for better outcomes.

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3 replies
lfitz | @lfitz | Sep 26, 2022
In reply to @stageivsurvivor "Early in my treatment on Folfirinox for metastatic disease to the liver, I got genetically tested..." + (show)
@stageivsurvivor

Early in my treatment on Folfirinox for metastatic disease to the liver, I got genetically tested and found to have a gene mutation. When the effectiveness of Folfirinox began waning, I enrolled in a clinical trial in 2014. I had a complete response resulting in NED since.

There are many types of clinical trials that are not dependent on having a gene mutation. There are drugs designed to interrupt/shut down the cell energy cycle of malignant cells. Immunotherapy targeting check-point inhibitors is another area of active research. PanCan.org and LetsWinPC.org have a clinical trials finder as does clinicaltrials.gov. There are several companies that will help narrow down potential trials that do the searches at no charge. Look into the websites EmergingMed.com, CancerCommons.org, myTomorrows.com and Ancora.ai. Clinical trials offer late-stage pancreatic cancer patients the potential for better outcomes.

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Thank you! We will start checking into these.

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Moderator
Colleen Young, Connect Director | @colleenyoung | Sep 26, 2022

@lfitz, in addition to the clinical trials resouces @stageivsurvivor offered, I might also add Mayo Clinic's Clinical Trial website. https://www.mayo.edu/research/clinical-trials

You can search for clinical trials for pancreatic cancer using the search tool on the site. But I think you might appreciate speaking with a cancer trial coordinator. Here's how:

CANCER-RELATED CLINICAL STUDIES QUESTIONS
Phone: 855-776-0015 (toll-free)
Online form: https://www.mayo.edu/research/forms/cancer-clinical-trials

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1 reply
lfitz | @lfitz | Sep 26, 2022
In reply to @colleenyoung "@lfitz, in addition to the clinical trials resouces @stageivsurvivor offered, I might also add Mayo Clinic's..." + (show)
@colleenyoung

@lfitz, in addition to the clinical trials resouces @stageivsurvivor offered, I might also add Mayo Clinic's Clinical Trial website. https://www.mayo.edu/research/clinical-trials

You can search for clinical trials for pancreatic cancer using the search tool on the site. But I think you might appreciate speaking with a cancer trial coordinator. Here's how:

CANCER-RELATED CLINICAL STUDIES QUESTIONS
Phone: 855-776-0015 (toll-free)
Online form: https://www.mayo.edu/research/forms/cancer-clinical-trials

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Thank you!

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lvtexas | @lvtexas | Sep 27, 2022
In reply to @stageivsurvivor "Early in my treatment on Folfirinox for metastatic disease to the liver, I got genetically tested..." + (show)
@stageivsurvivor

Early in my treatment on Folfirinox for metastatic disease to the liver, I got genetically tested and found to have a gene mutation. When the effectiveness of Folfirinox began waning, I enrolled in a clinical trial in 2014. I had a complete response resulting in NED since.

There are many types of clinical trials that are not dependent on having a gene mutation. There are drugs designed to interrupt/shut down the cell energy cycle of malignant cells. Immunotherapy targeting check-point inhibitors is another area of active research. PanCan.org and LetsWinPC.org have a clinical trials finder as does clinicaltrials.gov. There are several companies that will help narrow down potential trials that do the searches at no charge. Look into the websites EmergingMed.com, CancerCommons.org, myTomorrows.com and Ancora.ai. Clinical trials offer late-stage pancreatic cancer patients the potential for better outcomes.

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What specific clinical trial were you in? And is it standard of care now?

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sprinter345 | @sprinter345 | Oct 3, 2022

My husband is in the gem Abraxane plus pamrevulab and of the Precision Promise trial. The CA 19-9 has gone down from 4700 to 600 so far, 6 cycles completed, no tumor growth but no shrinkage. But now platelets are low so we have to take a couple weeks off.
Would love to know what genetic marker the Texas person had - my husband has the KRAS G12V and ATM

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1 reply
Moderator
Colleen Young, Connect Director | @colleenyoung | Oct 7, 2022
In reply to @sprinter345 "My husband is in the gem Abraxane plus pamrevulab and of the Precision Promise trial. The..." + (show)
@sprinter345

My husband is in the gem Abraxane plus pamrevulab and of the Precision Promise trial. The CA 19-9 has gone down from 4700 to 600 so far, 6 cycles completed, no tumor growth but no shrinkage. But now platelets are low so we have to take a couple weeks off.
Would love to know what genetic marker the Texas person had - my husband has the KRAS G12V and ATM

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Welcome @sprinter345. I believe your question about genetic markers was directed to @lvtexas, who will hopefully return to share their genetic indicators.

Sprinter, will you resume trial treatment once the platelets have recovered?

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1 reply
lvtexas | @lvtexas | Oct 7, 2022
In reply to @colleenyoung "Welcome @sprinter345. I believe your question about genetic markers was directed to @lvtexas, who will hopefully..." + (show)
@colleenyoung

Welcome @sprinter345. I believe your question about genetic markers was directed to @lvtexas, who will hopefully return to share their genetic indicators.

Sprinter, will you resume trial treatment once the platelets have recovered?

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Hi All,

No genetic markers were identified for me.

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nhow234 | @nhow234 | Oct 15, 2022

I have heard of a pancreatic booster trial at John Hopkins, but have not looked into it.

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