Chronic pain after radiation for Stage IV Lung Cancer

Hello, I'm hoping to hear from someone else who has had this type of experience. My wife was diagnosed with Stage IV NSCLC back in November, 2020. She is non-smoker (never smoked). She had an EGFR mutation and did a targeted therapy for one year (Tagrisso). This helped a lot in the first few months but then it became ineffective at bringing down the numbers on her tumor markers and the PETs showed the same. She had 10 sessions of radiation which helped a lot but it also caused (or at least coincided with) great pain (chronic) in her right-side chest, arm and upper back. Then her tumor markers started going up again. She's doing chemotherapy now (Alimta and Carbo) and it's showing reduction in the tumor markers but she still has this pain (anywhere between 5 and 10 on the pain scale) even though she uses a Fentanyl patch and she takes Oxycodone and Tylenol as needed (usually 3-4 times per day). Also, she experiences lots of side effects and has trouble keeping any food down. We would really like to find the root cause of her pain rather than using pain blockers. Like I said, they don't seem to help with the pain all that much anyway and we don't know what other damage they may be causing.

Sorry for the long post but I would appreciate feedback or input from anyone who has had a similar situation. Thanks...tns