← Return to Was your endometrial cancer tested for mutations in the gene POLE?

Discussion
Comment receiving replies
@esikora

Sorry that the POLE test was negative. Did you have LVSI on your path report? Is that the rationale for the chemo?

Jump to this post


Replies to "Sorry that the POLE test was negative. Did you have LVSI on your path report? Is..."

I did have LVSI. That line of the report said "Present: Low (less than 3 vessel involvement)." When I asked the Dr. at hospital 2 why he was recommending pelvic radiation, he cited the GOG 249 clinical trial, where they found this to be equivalent to (or maybe slightly better than) 3 cycles of chemo + VB for high risk early stage patients such as myself. When I asked the NP at hospital 1 why they recommended chemo + VB, she said it was because my tumor was p53 positive. (I'm not convinced "positive" is the right word for the result: they did IHC on two slides containing tumor, and one was "focally positive" while the other appeared to be negative.)