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DiscussionWas your endometrial cancer tested for mutations in the gene POLE?
Gynecologic Cancers | Last Active: Apr 1 1:02pm | Replies (28)Comment receiving replies
Replies to "Sorry that the POLE test was negative. Did you have LVSI on your path report? Is..."
I did have LVSI. That line of the report said "Present: Low (less than 3 vessel involvement)." When I asked the Dr. at hospital 2 why he was recommending pelvic radiation, he cited the GOG 249 clinical trial, where they found this to be equivalent to (or maybe slightly better than) 3 cycles of chemo + VB for high risk early stage patients such as myself. When I asked the NP at hospital 1 why they recommended chemo + VB, she said it was because my tumor was p53 positive. (I'm not convinced "positive" is the right word for the result: they did IHC on two slides containing tumor, and one was "focally positive" while the other appeared to be negative.)