Letrozole and checking estrogen levels
I have been taking Letrozole for 6 months. Is there a test (ideally a test that is sensitive and can indicate if the AI is actually working) that can check my estrogen levels? The only Estradiol test I have had was one that was checked just to confirm "menopausal status" a few months after removal of ovaries. However, this test was not very sensitive as it was not sent to a special lab and the results were received in just a few hours. I would have anticipated a lower number, but my Oncologist indicated that it was not a very sensitive assay. I would just like another potential test option that is more sensitive/comprehensive if possible.
Thank you for any thoughts!
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Read the Femara insert that contains info on studies on the effects on estradiol levels. The insert says that even a 20% dose effectively eliminates that hormone or, I should say, reduces it to a level that is not detectable. I don't think there is a need to do testing but the doctor should explain this better!
Why don't the oncologists keep up with us? The websites that we frequent have the information that many oncologists don't have. Perhaps so many are not listening to our informed questions.
Glad you are getting another opinion!
I too was put on Femara AI, and have been asking for a baseline estrogen test which neither the Oncologist nor Gynocologist was finding necessary to do. The GYN told me not to bother because "finding out the results would drive me nuts!" She said just take the AI and don't ask questions! The Oncologist thought it might be a good idea but never actually bothered to order the bloodwork.
I finally out of personal interest got my GP to do a blood test for estrogen levels and Vitamin/Minerals etc. So that I know for myself what's going on.
My Estradiol score is 18 pmol/l. which is already extremely low for postmenopausal. I talked to my GYN again and she says, take the AI anyway!
Really don't get their logic, considering the after effects of AI are not to be understimated. Yes, they reduce the risk of cancer return, but it also increases cholesterol which could lead to heart issues and decreased bone density leading to osteoporosis. I already have all the symptoms of low estrogen. Should I really be decreasing it to what? Below 0?
I'm not convinced with the plan, if they don't explain to me why they have no interest in knowing from what level estrogen they start treatment, and to what level they aim to go. It's just "shut up and take the AI for 5 years"
I, too, was in the same situation and very frustrated with their lack of concern/interest in serum estrogen levels. They seemed so important during the Anastrozole study I was in. But when I "failed" the study, the estrogen levels were no longer important. Seemed very contradictory to me. I decided not to go on Letrozole, which was the next AI in line. The side effects/payout wasn't worth it for me. I am amping up my immune system for overall better health (guided by integrative medicine physician). It was a very difficult decision for me, but I don't want fear to run my life. I'm doing the best I can and what will, hopefully, work for me. There is no magic pill/program for everyone. We all need to support each other and do what we can to move forward and be positive. I wish all the best to you in your journey.
I took letrozole for 5 1/2 months then my oncologist said I could take a break because of extreme side effects. She now wants me to take exemestane to see what side effects I might experience. After 4 1/2 months my trigger thumbs are finally getting better. I'm trying to decide whether to go back on the AIS. I don't really want to put my body through this kind of test. I'm puzzled why the doctors aren't interested in tracking estrogen levels. My primary physician used to be a naturopath before cancer. She tracked my hormone levels because I was taking bioidentical HRT. I think I will have to go to her and pay out of pocket for a blood test to track estrogen levels. It's expensive and medicare won't pay for it. This is being a very difficult decision for me, as well, and I found your post helpful and hopeful! I don't want fear to run my life either. I'm still in the information gathering stage and seeking support. My oncologist has said that if I choose not to take the AIs she can only see me once a year to palpate the scar left by the bilateral mastectomy. Evidently there is no other screening available to track possible recurrance, and then if/when symptoms show up. I'm hoping my PCP will provide some support, as well. My Oncodx score was 11. ILC
I'm forever in the information gathering mode. Check out the book called "Radical Remission" by Kelly Turner. It was recommended to me by Dr. Stacy D'Andre, an integrative medicine specialist. It is fascinating and chock full of information! Building up your immune system is a key factor and having a positive attitude.
Thank you. I will look into that. Someone else mentioned that book. I am working on building my immune system and have started using a supplement called DIM. My naturopath had suggested I take that a few years ago, before my cancer diagnosis.
How long did you take anastrozole? I have taken it for two years for mbc4. I have felt the same pains at 69 yoa. May I ask, how old are you and stage of cancer? I stopped taking the anastrozole for week as of Monday. Dr started me on kisqali and anastrozole. I wanted to make sure I knew what was affecting me if I felt like the pits and I do. Feel like severe case of flu and only taking one instead of 3 kisqali pills daily. Reason being I got so sick with verzenio and Ibrance. Dr wants me to try Letrozole with the kisqali when I run out of anastrozole. Did you use letrozole? I just get so nervous trying different meds.
@mhsosa I took Anastrozole for 2 3/4 yrs. I’m 69 & had a small stage 1 tumor. I’ve been off Anastrozole for almost 6 months ( mid October) and am feeling back to my normal. I’m a healthy active almost 70 (in 2 months).