I had to Google TKR.

I am plagued by SEVERE sciatica, with bulges at L1-2, L2-3, and L3-4. And I am getting all the PT that my body can handle and my medicare will pay for.

Have you considered cannabis internally or CBD oil topically? I can personally vouch for tokes taking pain and swelling away.

I am on such an olio of scripts I am not quite sure what is doing what what. But Duloxetine (Cymbalta) is the 'heaviest'. The rest are BP and digestive related and not as 'critical'.

I had seen something, I believe here at the Mayo site, about depressants being prescribed for some neuropathy, neuralgia, and Radiculopathy.

And though mine was scripted for my depression and anxiety, when I was cut cold turkey due to incompetence at my former Dr., the CHEST pain I was feeling from esophageal issues almost landed me in an ER. Or morgue.

I am also taking Gabapentin supposedly for pain.

At least that's why we give it to our cats with stomatitis.

It seems rather 'immediate' - 30 minute to take affect - for them, but as I understood for me it is more a residual kind of effect. Take it for a week, or a month, and then look back and see if I have been feeling better.

Same with the Duloxetine (and ANY antidepressant). One doesn't pop one to feel better.

My mom is passed. She had both of her knees done without much incident.

Best of success. Keep up up to date on you progress.

(=^..^=)
KK