You mentioned a targeted therapy, has your biomarker testing shown a gene mutation; EGFR, KRAS, ALK, etc? The targeted therapies for some of those types of mutations can be very effective, with minimal side effects.
Sorry that you need to make this decision, they are never easy and rarely straight forward. Do you have a good team? I would be looking for thoracic specialist, at a major medical center. Best of luck to you, take care, Lisa