Hello Carleen, The last time I was at a multiple Myeloma conference was a few years back but at that time, there was no really great understanding of why some people got full blown myeloma, and some people never did. That being said at that time many people finished their long lives without ever getting it. The other tidbit of information I can give, and it really is a tiny bit, is that my husband developed an under active thyroid after 8 years with myeloma and many treatments down the road. This is well controlled with a daily medication. We are 10 and half years into the journey with multiple myeloma, he was diagnosed with advanced myeloma with bone disease, he is doing well. I remember being in my oncologists office 16 years ago and Mike Katz was on the cover of a cancer magazine because 10 years with myeloma was nothing short of a miracle, now it is a lot more common. If you have MGUS, live your life watch the numbers when you should, be kind to your bones and your kidneys, and try not to spend your time worrying.