Genetic testing...does anyone have the CHEK2 gene mutation?
I have had bilateral breast cancer. According to my genetic test, I do not have the BRAC1 or BRAC2 mutation...I have the very rare CHEK 2 mutation. Has anyone had this mutation? If so, what was your plan of action?
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I have Chek 2 and have been treated for prostate and breast cancer. I see my internist and Mayo oncologist and proton radiation oncologist each twice each year. So far I am doing well but hate tamoxifen 🤢!
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1 ReactionType Google Scholar onto your Google search bar. It will take you to 100's of articles about Chek2.
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2 ReactionsMy daughter has the CHEK2 mutation. She found out when she was enrolled in a study.
I had breast cancer 30 years ago. There is no history of any cancer in my family.
I will request a genetic study myself- I have another daughter and a son.
My daughter with the CHEK2 has been followed with mammogram, ultrasound and MRI after suspicious findings. So far, so good.
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1 ReactionI have the Chek2 gene and 2 of my 3 adult children recently tested positive for it. They are now being followed closely by their physicians who are familiar with this nasty gene.
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2 Reactions@dick61- I’m afraid that my other 2 children have it too.
It really scared us to find out of this gene mutation’s existence.
While irrational, I felt guilty giving the Chek2 gene mutation to my 2 adult children. However, they are medically intelligent and have become aggressive in watchful waiting. Makes me feel a tad better.
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2 ReactionsYou should not feel guilty. I'm sad that my son has my mutations, but it's nothing I did. I don't blame my parents for having passed anything on to me. They gave me life. My son had a 50/50 chance of inheriting 4 identified genetic mutations I had and he got all four! What are the odds of that? BRCA2, CHEK2, HNPP, and a rare unknown vascular variant. The genetic counselor said, "This one is weird. Only one other person has ever had it." I said, "It's my son!"
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1 ReactionI have the Chek 2 Kinase mutation. I now get a breast MRI once a year and regular mammogram once a year.
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2 ReactionsI did have genetic counseling myself to see if my daughter got her mutation from me. I tested negative for CHEK2- so it probably was passed from her father.
Of course I had breast cancer- now she has 2 factors.
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2 ReactionsTamoxifen used to make me sick to my stomach as well but when I switched to taking it before bed I stopped having this side effect. I've also heard a lot about switching manufacturers if you are experiences side effects.