Welcome @suwairi. Rising PSA can mean a number of different things.

You may wish to read these related discussions:
– Post prostatectomy: What do rising PSA levels mean? https://connect.mayoclinic.org/discussion/post-prostatectomy/
– PSA numbers: Questions about new treatments https://connect.mayoclinic.org/discussion/psa-numbers/

There are several reasons why one's PSA level may rise after being stable for a time. This article explains it well:
– PSA levels after prostatectomy https://www.medicalnewstoday.com/articles/323899.php

Here's an excerpt from the article:
"Seeing a rise in PSA level does not always mean that prostate cancer is returning or spreading. The test is very sensitive and can pick up small changes in PSA levels. Doctors will usually want to know how quickly levels of PSA in the blood are rising. To find this out, a person will need to have regular PSA tests. If levels of PSA remain stable or rise very slowly, treatment may not be necessary.

In some cases, high PSA levels in the blood are not due to cancer cells. Some factors that can affect PSA levels include:
– older age
– ethnicity
– medication
A doctor will take these factors and the person's medical history into account when looking at test results. This can help them decide if PSA levels are high enough to cause concern."

The PSA test alone is not enough to determine cause or next steps. I agree with @rso that it is time to discuss the treatment and the changes in your PSA with your oncologist. When is your next appointment with your oncologist?

My PSA also rose after two treatments. My oncologist and I decided the Pluvicto was not working and cancelled further treatments. Two weeks later my PSA plummeted from 37.6 to 7.2 and then three days later to 5.4

We're back on the Pluvicto treatment schedule.

I will say that the second dose caused me much major discomfort in my GI tract. My bowels and bladder were hard to empty for days. Managed to get past it, but I did think I was finished at that point. Depression, as we all know, is too real now.

My best wishes and prayers to all my comrades out there and their caretakers.

Could be Tumor Flare. Seems MCRPC doesn't like being attacked. I will report my Pluvicto process.