I understand many folks have minimal difficulty with rituximab and/or infusions..... but not me. They administered the pre-medications, but when the rituximab started, I had reactions and it was stopped in 15 minutes. More meds were given, and a second attempt had similar results. More meds were given and eventually they were able to continue and after 8 hours it was completed. Pretty bad body aches through the entire time. I sure felt better shortly after it was completed as well as the past couple days. The second infusion is supposed to be easier, so am looking forward to a better day on Tuesday.