Depression: What treatment can I try after so many years?

Yes, there are risks associated with taking them together but there are risks with most medications. They are keeping me afloat and able to function for now.

I take Duloxetine for depre://www.mcmasteroptimalaging.org/full-article/es/older-people-major-depression-duloxetine-paroxetine-sertraline-reduce-depression but I found this arricle. I found that Paxil didn't help my Major Depression syndrome enough. I was switched to it and have been satisfied with it ever since. I hope that you read the article below.
https://www.mcmasteroptimalaging.org/full-article/es/older-people-major-depression-duloxetine-paroxetine-sertraline-reduce-depression-259#:~:text=Conclusions-,In%20older%20people%20with%20major%20depression%2C%20duloxetine%20%2C%20paroxetine%20%2C%20and,more%20than%20fluoxetine%20or%20escitalopram%20.

I'd like to know if any of you struggling to manage medications, experiencing little relief, have had your psychiatrist process a Genesite test?
My results were amazing.
Contrary to current focus on SSRIs, my brain responds to MAOIs. I received a profile.
Most of the psychiatric drugs are included in the evaluation--not just anti-depressants.
Red indicates not for me.
Yellow...caution
Green...most appropriate match.
Hope this helps.

Good to know about and thanks 👍

@aethos: me too. I am on the Effexor and Wellbutrin combo and it works. Although the two drugs have similar functions they target more specific problems. The Effexor treats the depression and anxiety, whereas the Wellbutrin treats seasonal affective disorder and anxiety. So they do overlap a little.

You will laugh, but I found relief in Martha Stewart’s CBD Gummies! I buy them online through Green Wellness, & they taste delicious. I take 1 (10 mg CBD) at bedtime, & maybe one more during the day if I begin feeling that “hopeless” feeling. No THC in them, so safe to take drug tests, if required. No side effects that I could feel (antidepressants ALL gave me miserable side effects). These give me enough lift so I can shake off the hopelessness and start moving.

Since I last posted I have gone off Wellbutrin entirely, I was feeling way too bunched up, meaning anxious and decided to see if I felt better off of it. So far I do but know my time of feeling “ok” may not last. I am currently taking 60 mg Cymbalta and am weaning myself off of that slowly. Who knows, maybe I don’t need the meds anymore. This is the only way to find out. I have been taking anti-depressants for over 30 years.

I like CELEXA aka CITALOPRAM.
I’ve experienced NO side effects & have been on in for over a decade. It’s an anti-anxiety anti-depressant med that is very helpful.

I am going to my psych appointment today to find out the results of my Genotype. This is my last try at antidepressants as nothing is helping anymore after literally 56 years of dealing with major depressive disorder. I am at the end of my rope. With everything that is going on in the USA, I am just wanting to isolate, and I believe the world is an ugly place. I think about where could I go? At age 70 and being born an American citizen, I am so fearful and will be glad when it is all over and my quality-of-life stinks. I do not believe there is a God so no Bible thumping need reply. Thank you.

I don't want to take my meds anymore either. How do you titrate off Wellbutrin? I have been on only 150 mg for one year with no results that I can see.