I noticed the left side enlargement of my tongue in 2007. It was causing mild burning pain at the time.... enlargement stays all the time, severe pain 70% of tree time and moderate pain 30% of the time. Nothing has helped, colds make the pain in my mouth go up exponentially. I have seen at least 20 different docs including several at jax mayo clinic. They only think i tell the truth about the pain i am in bc of the marked swelling of my tongue. Every blood test is perfect except a mild ana positive sign. No one can help. Going on ten years. My life has been greatly diminished by the pain. I feel crazy.