@rlybolt, is the iron a short-term solution? Will you eventually go back on the HU when the anemia subsides? I hear of people who have to have the spleen removed..I wonder under what circumstances that occurs, and if they are able to continue with their platelet-reduction therapy. I also wonder if the spleen ever shrinks back to normal size. I fortunately don’t have to think about that, presently. Thanks for your input and best of luck with your therapies.