@joan26 the company itself, Amgen, has a list of side effects on their site https://www.prolia.com/how-prolia-works/how-prolia-works?PPC-accountype:MICROSOFT-campaign:BND_DTC_Decision_General_2021-searchterm:prolia+info-adgroup:Consideration_General_PHM-keywordid:p71881835869&gclid=64a5684744f018afcb720aa11fb637fe&gclsrc=3p.ds&&gclid=64a5684744f018afcb720aa11fb637fe

Most drugs will have a longish list of possible side effects, and many reactions will be reported. Prolia has helped some patients, but others have suffered side effects. I would talk to your doctor.

The hardest thing about Prolia is that when you stop or even skip doses, your fracture risk goes up unless you are on something else. My doc does not use it.

@callalloo what do you mean by "bisphosphonate analog"? I have never heard that term. Prolia is a monoclonal antibody that stops production of cells that cause bone loss.

I have posted before that my endo doctor will not use Prolia for me, and people here have asked why. I talked with him today and he said he does use Prolia and it is a good drug. However, he has concerns about the drop-off of protection when you go off, and the resulting potential for fracture. It can be followed by Reclast, sure. He joked that some MD's prescribe it before retirement so they don't have to deal with the end of treatment! He also said that the rise in bone density is consistent and steady over years (unlike Tymlos, which builds the most in the 1st 6 months, then the next 6 months, then starts to level off. Of course Tymlos builds better quality....)