Hi @jam5. I wish we could help answer your question but the only source for “What is the best of antiviral for Covid in a patient with pre-existing conditions of any Lymphoma and Afib” is your hematologist/oncologist and cardiologist, or Pharmacist. This is by prescription only and no one on our forum can answer this for you. Is your husband newly diagnosed with Covid or are you lining this up just in case?? If you find out, will you let us know, please?

However, I can help answer your question about the MYD88 Gene.

Medline Plus-Genetics provided this publication on their site which explains the MYD88 gene and its normal roll in the immune system. I’ve pasted the first paragraph here for you.

“The MYD88 gene provides instructions for making a protein involved in signaling within immune cells. The MyD88 protein acts as an adapter, connecting proteins that receive signals from outside the cell to the proteins that relay signals inside the cell. In particular, MyD88 transfers signals from certain proteins called Toll-like receptors and interleukin-1 (IL-1) receptors, which are important for an early immune response to foreign invaders such as bacteria. In response to signals from these receptors, the MyD88 adapter protein stimulates signaling molecules that turn on a group of interacting proteins known as nuclear factor-kappa-B. Nuclear factor-kappa-B regulates the activity of multiple genes, including genes that control the body's immune responses and inflammatory reactions. It also protects cells from certain signals that would otherwise cause them to self-destruct (undergo apoptosis).”
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Here’s the actual site about MYD88 with various sub-articles that might be helpful for you if you have other questions about that gene and any mutations/conditions. It’s a really good informational article. https://medlineplus.gov/genetics/gene/myd88/#conditions

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I think last year when we first starting chatting there was some question of your husband having WM? But I think that diagnosis is no longer in question as he has B-Cell Lymphoma. One of your questions at that time, was whether mutations for the MYD88 gene is always checked with a bone marrow biopsy/exam.
We all have that gene. But a specific, aquired mutation to the gene can signal WM. It is a way to help determine WM if it’s suspected.

What were the results of the test? Did it show a mutation to the MYD88 gene or is it just present?