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The good and bad of Prednisone for PMR

Polymyalgia Rheumatica (PMR) | Last Active: Jul 23, 2022 | Replies (32)
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@jfannarbor

You mentioned in your post of July 10 that PMR has genetic markers. This is the first I have heard of this. I have had my genome sequenced and a variant of interest was in the area of LGMD/2A which in its classical form affects the muscles of the shoulder girdle and hip girdle the same as PMR. My variant is on chromosome 15. What information can you give me to help me investigate to see if I have the genetic markers associated with PMR. How did you find this out?

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Replies to "You mentioned in your post of July 10 that PMR has genetic markers. This is the..."
Teri | @tsc | Jul 23, 2022

Hi @jfannarbor,Many articles about PMR and GCA mention that it frequently occurs in persons of Northern European ancestry and Scandanavians in particular. ""These disorders occur primarily in patients older than 50 years, in women more than men; they are propagated by antigen-driven cell mediated (TH1) immune mechanisms that may be associated with specific genetic markers, and they are highly responsive to corticosteroids." Giant Cell Arteritis and Polymyalgia Rheumatica, Robert Spiera, in Cecil and Goldman's Textbook of Medicine.

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