I'm on Verzenio for the past 6 months (for MBC). I had diarrhea/urgent need to go at the beginning but it went away after 6 weeks or so. I guess the body adapts. I try to take it 1 hr before any meals and slowly drink a glass of cold water when taking it, pretty much sip by sip. I think it helped to take it well before any meals and other meds -if any. Just writing to let you know that even if you experience some side effects at the beginning , at least in my case, they went away.