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Treating Osteoporosis: What works for you?

Osteoporosis & Bone Health | Last Active: Nov 3, 2023 | Replies (1084)

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@windyshores

@catluvr999 Tymlos and Forteo do not affect resorption the way the other drugs do, and works with the parathyroid. Do you have a doctor?

They may have some minimal impact:

"Tymlos acts like PTH, binding to one of the PTH receptors in your bone. The type of receptor it binds to and the way in which it binds promotes bone formation and minimizes the other function of PTH, namely bone resorption, and calcium release."

Anabolics like Tymlos and Forteo work mainly by building bone, whereas biphosphonates and Prolia work by affecting resorption. Tymlos and Forteo do not cause the dental/ONJ issues or atypical fractures that may happen (if rarely) with the other drugs.

Evenity does both and does carry the risk of ONJ or atypical fractures but is only used for one year.

It might reassure you that anabolics like Tymlos and Forteo may be used to heal the atypical fractures caused by biphosphonates (or PRolia).

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691592/

Background
"Bisphosphonates (BPs) are the most commonly used anti-osteoporotic drugs, which have been proven to reduce the risk of osteoporotic fractures. However, use of BPs, particularly for long periods of time, is associated with an increased risk of atypical femoral fracture (AFF). Healing of BP-associated AFF is usually delayed because of suppressed bone turnover. Teriparatide (TPTD), a recombinant form of parathyroid hormone (PTH), enhances bone healing in patients with delayed healing or non-union."

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Replies to "@catluvr999 Tymlos and Forteo do not affect resorption the way the other drugs do, and works..."

Thanks. Yes I have a primary doctor....and will finally get an Endocrinologist appt...Dr Gina Woods.... in October, who I'm hopeful won't jump to a fosamax/Alendronate recommendation like my doctor did. I only got in about 10 of my 20+ questions w my doctor during our virtual appt....during which I pressed for investigating possible secondary causes of my -2.8 hip t score, which she obliged in spite of saying my Z scores would be what indicates a possible secondary cause to blame and they don't.