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anniegk (@anniegk)

Getting off of Seroquel

Depression & Anxiety | Last Active: Jan 16 10:10am | Replies (674)

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I suffer from anxiety and depression.. put on seroquel 3 years ago because I couldn’t sleep.. worse thing ever.. been on 30 diff meds for depression but no luck.. I have been thru bouts of depression but none lasted this long (always come out of them with effexor and adderral) effexor pooped out and adderral makes me anxious. Could the Seroquel be effecting the Ssris or snris? I just and I have a gut feeling it’s the seroquel. I was on up to 300 mgs but now down to 25mgs per day.. still feeling strange and anxious and have just recently gone on clonopo because anxiety is so hi. I hate that too because I have been on so many benzo and had been off for a month but had to go back on because anxiety is thru the roof.. should I try another ssri or snris? Something natural to rid Seroquel of my system? Doc suggested St. John’s wort but read that was just for mild depression. Just so confused! Someone else recommended ketermine injections.. any suggestions would be greatly appreciated. By the way, I did TMS with no luck and had hormones tested. I did 6 months of testerone pellets ibut didn’t work so I stopped. Could the atop in testosterone be causing the anxiety?

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Replies to "I suffer from anxiety and depression.. put on seroquel 3 years ago because I couldn’t sleep....."

Something to know:
"Quetiapine, is sold under the brand name Seroquel".
In general, drugs are metabolized in the liver by enzymes – this allows them to be broken down and removed.
This is important since drugs are prescribed according to dose and body weight etc.
If drugs are not metabolized and removed, the drug or drugs given would accumulate and result in the wrong dose or possible toxic dose. In this case, the resulting symptoms would be different than expected.
You can ask your doctor if this might be a problem.
The drugs you mention are typically metabolized in the liver, by the "cytochrome P450 (CYP) enzyme system".
Age, damage or disease of the liver* can result in a reduced rate of breakdown of a drug or drugs and accumulation also. (*See Mayo Clinic "Liver Function, lab serum tests")
Some more, particular information about this:
Quetiapine or Seroquel is metabolized by an enzyme in the liver that is genetically reduced or lacking in some people.
"Seroquel is metabolized by the liver cytochrome P450 (CYP3A4) enzyme".
"Clozapine is metabolized in the liver primarily by the cytochrome P450 (CYP1A2) enzyme".
[from: J Psychiatry Neurosci. 2003 Mar; 28(2): 99–112]
If you happen to genetically lack one of these liver enzymes, you should avoid the drugs that are metabolized by them.