I was put on Arava and lasted maybe 2 months until my liver enzymes went way too high and my rheumatologist took me off of it immediately. Before that I was on methotrexate which I injected myself. One night I had a mild anaphylactic reaction after my last methotrexate shot. That had never happened to me before, even when I was on methotrexate in the early 2000s. My methotrexate was discontinued. Next week I am going to go onto an infusion of Orencia, a biologic. Hint about finances: if anyone is on Medicare and needs a biologic, make sure you can get an infusion; Medicare Part B picks up the tab for infusion treatments of certain biologics.