In the first few months on a new treatment (usually 60-90 days) you can see your tumor markers rise due to the meds killing off cancer. Those dead cells are released into the blood stream and can make it look like your markers are rising but it's for a good reason. Once die-off slows down you see your markers drop down. This is why they tell you not to worry too much at first if your markers rise. It is not always due to progression. I hope that explains it.
Peggie