@mandm4evers As @loribmt said, I have multiple myeloma. I have had abnormal protein levels in blood and urine for decades. Going back to 1988, I have had more 24-hour urine collections than I can recall! The sophistication of testing and garnering accurate results over that time has been astounding. In 1988 the diagnosis of Systemic Lupus was the result of many types of testing and eliminating conditions based on results. In addition to the abnormal protein, later labs determined there was more going on when coupled with results I was used to seeing. It took an astute nephrologist who connected the dots and saw what others had failed to note, to get me on the correct track now, bless her heart! Yes, I still have the ultra-rare kidney disease officially diagnosed in 2015, and that is what is shutting down my kidneys. But it has no relation to multiple myeloma. The bone marrow biopsies offer an accurate insight to where my myeloma is at, what percentage of the blood plasma is affected, and allows the doctor to be accurate in his treatment. Because there is a kidney disease and the myeloma, the protocol is a bit different than it might be for someone else.

The Bence-Jones protein is what a doctor may be looking for in your urine, that might indicate a blood plasma issue. In my case, I do not have that, proving my kidney issue is separate from the myeloma.

Here is the link to Mayo Clinic's explanation of bone marrow biopsy: https://www.mayoclinic.org/tests-procedures/bone-marrow-biopsy/about/pac-20393117
Do you have any further question I can answer, or comfort I may offer to you?
Ginger