Hi @macferse, Sorry to hear you experienced bad sciatica pain when tapering down on the Prednisolone. You will notice that we moved your post to a similar discussion on the same topic here - PMR and Sciatica with Back Pain: https://connect.mayoclinic.org/discussion/pmr-and-sciatica-with-back-pain/. We did this so that you can connect with other members like @milld835, @anniekirby, @cjh51, @virginiaj and @susi451 who may have some thoughts on your question of is the sciatica just a coincidence or is there any evidence of a link.