There are people who simply cannot tolerate statins. I'm one of them. I have tried every one on the market and all of them caused horrendous leg cramping. I mean the kind of cramp where the ankle bends forward so toes are trying to reach shinbone and knee bends so severe that my heel was essentially trying to reach the thigh back. Essentially, my leg accordion pleated and the pain was frightening. I almost called 911 once because I was afraid that I could permanently damage muscles or tendons. (I later found that severe enough cramping can actually do that. ) My cardiologist has other patients who've had the same reaction to those drugs.

I never had a leg cramp in my life before playing with statins. It's been four years since I last took one and the cramps have, slowly, become less severe and less frequent. Buy they're not 100% gone yet either. I've never found the explanation for how/why statins can do this, but it's not uncommon.

For others who have this issue, I've found that I can stop a cramp if, at the very first twitch/sensation, I immediately grab an ice pack and essentially 'pet' (think stroking a puppy) the whole length of the leg. IF I can ice the area soon enough, the full cramp never materializes and muscles slowly reverse the seizing-up process. But the fact that statins caused this intense trigger reaction that is tenacious enough to still cause a problem after this much time is curious to me.
What else do those drugs do?