I also have MAC and am taking the big 3. I also use CBD but not on the days I take the big 3. CBD is anti-inflammatory which is why I use it. But a pharmacist explained to me that azithromycin increases the concentration of CBD and rifampin reduces the concentration. That
may be a wash. But I don't think there are any studies on CBD usage and the big 3. So just to be safe, I only use CBD on the 4 days that I don't take the big 3.
Lora Jo