My eye doctor recommended that I start taking PreserVision Areds 2 since I have early stage of macular degeneration. Yes, I had stomach discomfort for a week after I started taking PreserVision Areds 2. So I stopped. When is in this vitamin that causing stomach issues? I am on RA meds plaquenil 200 mg 1 X a day and 4 methotrexate sodium 2.5 mg 1X a week.