Amgen has a black box warning on the insert (which most patients do not see unless you open the package and read it before handing over to the nurse/doctor giving the injection) advising not to stop taking Prolia cold turkey. I have read it. On Prolia for 4 yrs and would have to transition off on to Reclast. 100% you cannot just quit taking Prolia without backup plan or at high risk for fracturing.