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Low T-Cell - Bone Marrow Biopsy
Blood Cancers & Disorders | Last Active: Nov 15, 2022 | Replies (162)Comment receiving replies
Antibodies are large proteins of the immune system that neutralize intruders, such as bacteria, viruses, fungi, and parasites. There are five main types of antibodies: IgA, IgD, IgE, IgG, and IgM.
To assist you in understanding IgG, IgM and IgA, I found some good articles and videos which do much better job explaining the differences than I can. I hope you find them beneficial.
IgM = Immunoglobulin M antibodies.
https://labs.selfdecode.com/blog/immunoglobulin-m/
Waldenstrom Macroglobulinemia cells make large amounts of a certain type of antibody (immunoglobulin M, or IgM), which is known as a macroglobulin. Each antibody (protein) made by the WM cells is the same, so it is called a monoclonal protein, or just an M protein.
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This video shows the differences between IgG and IgA serology tests and what the results can mean.
Though slow and as exciting as watching paint dry, this video lists each of the Antibodies, their structures and functions.
https://youtu.be/VctTbhhw8do
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In reference to the Kappa and Lamba light chains, they are primarily used in the typing of myeloma patients and determining the degree of disease in MM, B-cell Lymphomas and W/M patients.
This article helps give an understanding of a light chain and how the information is used in diagnosing blood disorders.
https://www.myelomacrowd.org/myeloma/community/articles/kappa-lambda-light-chain
There are several National Institute of Health articles on using light chain in determination of B-cell lymphoproliferative disorders.
https://pubmed.ncbi.nlm.nih.gov/16740039/
https://www.cancer.org/cancer/waldenstrom-macroglobulinemia/about/what-is-wm.html
I know you have WM and B Cell lymphoma. How have you been doing since your Rituximab infusions? Have your symptoms progressed?
Replies to "Antibodies are large proteins of the immune system that neutralize intruders, such as bacteria, viruses, fungi,..."
Thank you very much I will re read the information
The last diagnosis from the oncologist was MZL- nodal type; however there seems to be several overlapping areas concerning light chain numbers.
He also is in persistent afib , on Xarelto 20mg each day, along with cardiac amyloidosis with a smaller concomitant amount of AL
For now, continuing active surveillance.
Renal US showed 4 L kidney stones and cyst, R kidney 1 stone and cyst, and bladder containing 40+ gravel/sand. Started on alopurinol 100mg every day as of 9/10/22.
received 2nd Evusheld on 9/12/22
Kappa free light chain 180.7 H
Lambda " " ' 10.63
Kappa/Lambda ratio - 17.55
Serum
IgG =3054 H
IgM=13 L
IgA =13 L
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Thank you so much for sending all of this information
I will read and look at each one.
Currently the diagnosis seems to be Mantle Cell Lymphoma; however, it is complex with a lot of overriding factors due to wild type cardiac amyloidosis with a smaller amount of cardiac AL confirmed with myocardium biopsies.
So far keeping up with vaccines, boosters and Evusheld due to the B cell depletion from Rituxan.
Active surveillance with Follow up in 3 months.
It has been very stressful and isolating with limitation's and cancellations on travel plans and any indoor group interactions.
Your interest is greatly appreciated.
JAM5