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Low T-Cell - Bone Marrow Biopsy

Blood Cancers & Disorders | Last Active: Nov 15, 2022 | Replies (162)

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@loribmt

Antibodies are large proteins of the immune system that neutralize intruders, such as bacteria, viruses, fungi, and parasites. There are five main types of antibodies: IgA, IgD, IgE, IgG, and IgM.
To assist you in understanding IgG, IgM and IgA, I found some good articles and videos which do much better job explaining the differences than I can. I hope you find them beneficial.

IgM = Immunoglobulin M antibodies.
https://labs.selfdecode.com/blog/immunoglobulin-m/

Waldenstrom Macroglobulinemia cells make large amounts of a certain type of antibody (immunoglobulin M, or IgM), which is known as a macroglobulin. Each antibody (protein) made by the WM cells is the same, so it is called a monoclonal protein, or just an M protein.
~~~~~
This video shows the differences between IgG and IgA serology tests and what the results can mean.
https://youtu.be/2eRpntScCmI

Though slow and as exciting as watching paint dry, this video lists each of the Antibodies, their structures and functions.
https://youtu.be/VctTbhhw8do
~~~
In reference to the Kappa and Lamba light chains, they are primarily used in the typing of myeloma patients and determining the degree of disease in MM, B-cell Lymphomas and W/M patients.
This article helps give an understanding of a light chain and how the information is used in diagnosing blood disorders.

https://www.myelomacrowd.org/myeloma/community/articles/kappa-lambda-light-chain

There are several National Institute of Health articles on using light chain in determination of B-cell lymphoproliferative disorders.

https://pubmed.ncbi.nlm.nih.gov/16740039/https://www.cancer.org/cancer/waldenstrom-macroglobulinemia/about/what-is-wm.html

I know you have WM and B Cell lymphoma. How have you been doing since your Rituximab infusions? Have your symptoms progressed?

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Replies to "Antibodies are large proteins of the immune system that neutralize intruders, such as bacteria, viruses, fungi,..."

Thank you so much for sending all of this information
I will read and look at each one.
Currently the diagnosis seems to be Mantle Cell Lymphoma; however, it is complex with a lot of overriding factors due to wild type cardiac amyloidosis with a smaller amount of cardiac AL confirmed with myocardium biopsies.
So far keeping up with vaccines, boosters and Evusheld due to the B cell depletion from Rituxan.
Active surveillance with Follow up in 3 months.
It has been very stressful and isolating with limitation's and cancellations on travel plans and any indoor group interactions.
Your interest is greatly appreciated.
JAM5

Thank you very much I will re read the information
The last diagnosis from the oncologist was MZL- nodal type; however there seems to be several overlapping areas concerning light chain numbers.
He also is in persistent afib , on Xarelto 20mg each day, along with cardiac amyloidosis with a smaller concomitant amount of AL
For now, continuing active surveillance.
Renal US showed 4 L kidney stones and cyst, R kidney 1 stone and cyst, and bladder containing 40+ gravel/sand. Started on alopurinol 100mg every day as of 9/10/22.

received 2nd Evusheld on 9/12/22
Kappa free light chain 180.7 H
Lambda " " ' 10.63
Kappa/Lambda ratio - 17.55
Serum
IgG =3054 H
IgM=13 L
IgA =13 L