I’ve had this problem for over 5 years as an elderly pst-menopausal woman with DM well controlled. I had a complete hysterectomy at age 34 so estrogen lacking. Lots of things add up to chronic UTI that can become resistant which I am right now to oral meds. So I’m on a PICC line IV and fingers crossed it works like the one 2 years ago. I did two weeks of some wicked antibiotics IV and then I was able to take macrobid again until I became resistant. The sad part of this is it’s a worldwide problem with not many answers. I almost flew to the country of Georgia where they still do phage therapy. Now there’s something to Google! Anyway hang in there and find the best urologist in your area. Some my problem is with a tiny kidney stone. They hold infection.