Have you tried the new Protocol 525 product for neuropathy relief?

Thank you team
Finished the RUP YESTERDAY

STARED THA PROCAL TODAY.
truly truly placing all my trust and faith unlike any previous
Dr treatments are made made
Chemical.
And thank you John for talking about it ok .

Mayo has been my hope unlike many many other things tried. Including a surgery decision 6 yrs back.

Blessings to all with this debilitating condition.

By for now.

John, Have you continued with the new Protocol 525? Has whatever Protocol 525 you are taking continued to help your neuropathy? My neuropathy thankfully does not cause pain but causes serious balance issues. Do you know if the Protocol addresses that issue? Thanks for any advice you can give me.

@gthalbrooks I have been taking the protocol since Sept 2016, mainly because I feel it is helping with the neuropathy even though I also have no pain. I have seen a little feeling return to the feet. Kind of hard for me to judge since I have to wear compression socks daily for lymphedema to control the swelling in the legs. I think they add to the problem. Not sure the protocol does much for the balance but I do try to work on balance exercises and I also have the senior shuffle down pat for the winter time. You might find the following discussion helpful:

Having trouble keeping your balance?: https://connect.mayoclinic.org/discussion/having-trouble-keeping-your-balance/

John,
Thanks for your kind and thoughtful response. Since along with numbness balance is my major issue, I think I’ll wait. I have an upcoming appointment with a new neurologist at Duke who just came after six years at Mayo in Rochester. I’ll see what she thinks. Thanks again for your help.
Tom

John,
Thanks also for the balance exercises!
Tom

Hi John, I am considering the protocol (it is expensive though) I have read through most of this forum and found one spot that talks about ala And rala.. plus the s form of it. I have concerns about the dental amalgums with it pulling the mercury out. Do you think that this will cause harm.. if maybe we cut back to the 600mg / day ? And if I am purchasing my own, is the suppliments that have 300 mg of s and 300mg of r ok ? Or do we need pure r Ala? Since a lot of talk about rebuilding nerves is from the rala.

Hi Ron @ronlud, Welcome to Connect. From my research only the natural form of alpha lipoic acid helps with neuropathy which is why I think the R-ALA costs a little more. Most of the cheaper product brands contain 50% synthetic ALA (S-ALA) and 50% R-ALA). You can find a lot of research papers on the topic of myelin using Google Scholar - https://scholar.google.com/. Probably one of the better sites for details of ALA is Lipoic Acid - Linus Pauling Institute: https://lpi.oregonstate.edu/book/export/html/373

I haven't done much research on dental work and mercury but it might be a question for your doctor or pharmacist. I have quite a few fillings plus an implant and haven't noticed any problems and I've been taking the ALA 600mg of the cheap stuff before starting the protocol in 2016 when I started taking 1200mg of the R-ALA. I do know there are some files on the topic in Solutions to Peripheral Neuropathy Pain & Discomfort Facebook group files (http://facebook.com/groups/spnpd).

Here's a research paper on the topic - hurts my brain to read it 🙂-- White Paper: FDA Update/Review of Potential Adverse Health Risks Associated with Exposure to Mercury in Dental Amalgam: https://www.fda.gov/medical-devices/dental-amalgam-fillings/white-paper-fda-updatereview-potential-adverse-health-risks-associated-exposure-mercury-dental

What type of neuropathy do you have? Can you share a little more about your symptoms and treatments you've tried?

Thanks John,
Just to make sure I understand your response. You would reccomend the pure r-alpha over the mixed ? As the pure should work better. ( I wish it was less expensive)
Background: I've had the numbness under or maybe I should say thickness in between my toes and balls of my feet for years, but after getting a covid shot, this feeling has started to spread, and sometimes the bottom of my foot feels bruised, like I was hit with a baseball bat on tHe balls of my foot. (That comes and goes) , sometimes a tightness in the tops ofmy feet like a slight sunburn, I also came down with foot drop ( mainly in my big toe, using nmes stimulation for that) ) sent to neurologist , to nerve Dr for the nerve tests in my legs, to mri of spine, to spine Dr, to spine surgeon . And back to neurologist specialist.
Was told I have periphrial neuropathy (mainly because I have diabeties, even though I keep my a1c levels around 6.3. As soon as they see diabeties.. that's the cause, no other discussion about it) and a bulging disk (l5-s1) (and spondilolithisus) compressing nerve root. He wanted to fillet me like a fish, remove the disc and do a fusion. I said, let's try some decompression and pt first. Decompression is working for my back,
I've also been on prednisone for a couple years for pmr.. tapering off of it, down to 6mg. I would like to get ahead of any nerve damage I have so I can walk better ( also have had loss of strength , so I can't walk very far, legs / arms ache ) all kinds of blood work done, low on b6, end e. Started suppliments for those (a b complex so im getting all the b's) along with magnesium glyconate (for muscle twitching) I retired in 2020 and someone flipped a switch on my body and it's decided it's had enough.
I believe I'm taking e erything in the protocol (minus the hemp and r-ala) there may be one or two more . Just don't remember them.

Also, reading the one report it states : It has been suggested that the presence of S-lipoic acid in the racemic mixture may limit the polymerization of R-lipoic acid and enhance its bioavailability. At present, it remains unclear which supplemental form is best to use in clinical trials.
So it may be better to use the mix ?

I really have no expertise but everything I've read says the S-ALA which is a byproduct in making the R-ALA supplement is inactive and really doesn't do anything to help. I think it's just cheaper to leave it in instead of refine the product more to take out the S-ALA for a 100% R-ALA product. This article has an easier to read and understand explanation...

(R)-Lipoic Acid: Unique ‘Mitochondrial Antioxidant’ Fights Premature Aging: https://nutritionreview.org/2019/07/r-lipoic-acid-unique-mitochondrial-antioxidant-fights-premature-aging/

I wouldn't purchase the version with S-ALA even if it's cheaper, but that's just my opinion.