I have osteoporosis and several years ago my doctor put me on Prolia (I also have a compressed fracture in my back). I have had no problems at all with the drug, no side affects, no pain. I had been on Fosamax for I think 10 years before this. I am thrilled with my success on Prolia - a 6% increase in bone density. I have a bone density study scheduled for August. I admit I did not do a lot of research when I started and reading now that it seems I need to be on it for life (I am 70) is concerning. I will discuss with my doctor at my next appointment what the future might hold. Its obviously a really important decision for you, good luck.