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Mycophenolate & Tacrolimus: Anyone have elevated liver enzymes?
Transplants | Last Active: May 29, 2022 | Replies (8)Comment receiving replies
Thanks so much @edb1123 for jumping in to help me! 😊 Approximately how high did your liver enzymes go? I am a kidney transplant patient and my liver enzymes have been elevated since my transplant two years ago. After CMV virus, my Cellcept was reduced and my liver enzymes improved but are still elevated. I am coming up to two years of elevated liver enzymes and for the last six months my BUN level is also going higher. From what I am reading on the internet, it can be caused by Cellcept, Tacronlimis and sometimes the combination. (I also read that BUN can relate to liver function, which I did not know). I am concerned that they may need to change my meds which scares me about possible rejection. I am also not sure which drug they will change the Tac or the Cellcept MMF...or reduce first. It sounds like you needed the Tac to solve your liver enzymes increase. I think I am going to need a reduction of one of them (or a change). As usual, I am high anxiety about possible liver damage after two years, my higher BUN level, and the possibility of rejection when there is a change in medication. So, I decided to post and hear other people's experiences, like your successful story! Thank you for sharing your story. It's very helpful. 😊
Replies to "Thanks so much @edb1123 for jumping in to help me! 😊 Approximately how high did your..."
Hello, hello 1234! 😊
Yes, I looked back at my test results from last May and June, and my AST was 630 vs. normal max of 43, my ALT was 836 vs. normal max of 45, and my Alkaline Phosphatase was 219 vs. normal max of 104. I don’t think I ever had a BUN test - it may be unrelated to bone marrow transplants. I’ve never taken Cellcept, so I can’t comment on the difference between that and Tacrolimus. In my case, I believe the high dose of Prednisone is what resolved the liver enzyme issues. I hope you get the necessary medication to resolve your issues!
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@hello1234 My husband recently had elevated liver enzymes also. He is almost 6 years out from his transplant. When I mentioned your post, he said he figured his results were caused by his lifestyle for a while. He was away from the house here, camping and working a contract job. He was drinking more than usual, and eating a lot of restaurant food. When he came home he went back to the "regular" diet he had been on, and told me his values dropped back towards what they had been.
Not sure if I can convince him to look more into the values to see if he has the same issues as you, though. I will be interested to hear what his doctor thinks, and especially the transplant team he will see in a couple months for his annual check-up.
Ginger