Lisa, Annatto Tocotrienol distinguishes itself from tocotrienol found in other sources like red palm oil or rice by being virtually free of tocopherols - vitamin E also known as alpha tocopherol. Tocotrienol competes with tocopherol for absorption. Alpha-tocopherol administration has also been found to decrease the gamma-tocotrienol concentration in the adipose tissue and skin, inhibiting both delta and gamma tocotrienol tissue uptake. The importance of taking advantage of annatto tocotrienol begins with it's unhindered absorption in breast tissues by alpha-tocopherol. Since annatto tocotrienol is fat soluble it should be taken with a meal to enhance absorption. The first link expands on adipose tissue mentioned earlier. The others a little more on annatto tocotrienol.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460846/#:~:text=Breast%20lobules%20and%20ducts%20are,the%20breast%20microenvironment%20%5B3%5D.
https://pubmed.ncbi.nlm.nih.gov/20188744/#:~:text=2%2Fneu%20expression-,Gamma%2D%20and%20delta%2Dtocotrienols%20exert%20a%20more%20potent%20anticancer%20effect,Life%20Sci.
https://www.todaysgeriatricmedicine.com/archive/SO19p24.shtml